A Governance and Evaluation Framework for Deterministic, Rule-Based Clinical Decision Support in Empiric Antibiotic Prescribing

ArXi:2603.10027v1 Announce Type: cross Empiric antibiotic prescribing in high-risk clinical contexts often requires decision making under conditions of incomplete information, where inappropriate coverage or unjustified escalation may compromise safety and antimicrobial stewardship. While clinical decision- systems have been proposed to assist in this process, many approaches lack explicit governance and evaluation mechanisms defining scope, abstention conditions, recommendation permissibility, and expected system behavior.