Multimodal Protein Language Models for Enzyme Kinetic Parameters: From Substrate Recognition to Conformational Adaptation

ArXi:2603.12845v1 Announce Type: new Predicting enzyme kinetic parameters quantifies how efficiently an enzyme catalyzes a specific substrate under defined biochemical conditions. Canonical parameters such as the turnover number ($k_\text{cat}$), Michaelis constant ($K_\text{m}$), and inhibition constant ($K_\text{i}$) depend jointly on the enzyme sequence, the substrate chemistry, and the conformational adaptation of the active site during binding.