AI RESEARCH
Central Dogma Transformer II: An AI Microscope for Understanding Cellular Regulatory Mechanisms
arXiv CS.LG
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ArXi:2602.08751v3 Announce Type: replace Current biological AI models lack interpretability -- their internal representations do not correspond to biological relationships that researchers can examine. Understanding gene regulation requires models whose learned structure can be directly interrogated to generate experimentally testable hypotheses. CDT-II mirrors the central dogma in its architecture -- DNA self-attention, RNA self-attention, and cross-attention for transcriptional control -- requiring only genomic embeddings and raw per-cell expression.