Self-supervised Disentanglement of Disease Effects from Aging in 3D Medical Shapes

ArXi:2603.15862v1 Announce Type: cross Disentangling pathological changes from physiological aging in 3D medical shapes is crucial for developing interpretable biomarkers and patient stratification. However, this separation is challenging when diagnosis labels are limited or unavailable, since disease and aging often produce overlapping effects on shape changes, obscuring clinically relevant shape patterns. To address this challenge, we propose a two-stage framework combining unsupervised disease discovery with self-supervised disentanglement of implicit shape representations.