AI RESEARCH
Cell-cell Communication Inference and Analysis: Biological Mechanisms, Computational Approaches, and Future Opportunities
arXiv CS.AI
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ArXi:2512.03497v2 Announce Type: replace-cross In multicellular organisms, cells coordinate their activities through cell-cell communication (CCC), which is crucial for development, tissue homeostasis, and disease progression. Recent advances in single-cell and spatial omics technologies provide unprecedented opportunities to systematically infer and analyze CCC from these omics data, either by integrating prior knowledge of ligand-receptor interactions (LRIs) or through de novo approaches.