AI RESEARCH
G2DR: A Genotype-First Framework for Genetics-Informed Target Prioritization and Drug Repurposing
arXiv CS.LG
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ArXi:2603.20346v1 Announce Type: cross Human genetics offers a promising route to therapeutic discovery, yet practical frameworks translating genotype-derived signal into ranked target and drug hypotheses remain limited, particularly when matched disease transcriptomics are unavailable. Here we present G2DR, a genotype-first prioritization framework propagating inherited variation through genetically predicted expression, multi-method gene-level testing, pathway enrichment, network context, druggability, and multi-source drug--target evidence integration.