AI RESEARCH
ZeroFold: Protein-RNA Binding Affinity Predictions from Pre-Structural Embeddings
arXiv CS.LG
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ArXi:2603.23583v1 Announce Type: cross The accurate prediction of protein-RNA binding affinity remains an unsolved problem in structural biology, limiting opportunities in understanding gene regulation and designing RNA-targeting therapeutics. A central obstacle is the structural flexibility of RNA, as, unlike proteins, RNA molecules exist as dynamic conformational ensembles. Thus, committing to a single predicted structure discards information relevant to binding.