AI RESEARCH
Spectral Coherence Index: A Model-Free Metric for Protein Structural Ensemble Quality Assessment
arXiv CS.AI
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ArXi:2603.25880v1 Announce Type: cross Protein structural ensembles from NMR spectroscopy capture biologically important conformational heterogeneity, but it remains difficult to determine whether observed variation reflects coordinated motion or noise-like artifacts. We evaluate the Spectral Coherence Index (SCI), a model-free, rotation-invariant summary derived from the participation-ratio effective rank of the inter-model pairwise distance-variance matrix.