Longitudinal Boundary Sharpness Coefficient Slopes Predict Time to Alzheimer's Disease Conversion in Mild Cognitive Impairment: A Survival Analysis Using the ADNI Cohort

ArXi:2603.26007v1 Announce Type: cross Predicting whether someone with mild cognitive impairment (MCI) will progress to Alzheimer's disease (AD) is crucial in the early stages of neurodegeneration. This uncertainty limits enrollment in clinical trials and delays urgent treatment. The Boundary Sharpness Coefficient (BSC) measures how well-defined the gray-white matter boundary looks on structural MRI. This study measures how BSC changes over time, namely, how fast the boundary degrades each year works much better than looking at a single baseline scan for predicting MCI-to-AD conversion.