Lingshu-Cell: A generative cellular world model for transcriptome modeling toward virtual cells

ArXi:2603.25240v1 Announce Type: cross Modeling cellular states and predicting their responses to perturbations are central challenges in computational biology and the development of virtual cells. Existing foundation models for single-cell transcriptomics provide powerful static representations, but they do not explicitly model the distribution of cellular states for generative simulation. Here, we