Gradient estimators for parameter inference in discrete stochastic kinetic models

ArXi:2604.02121v1 Announce Type: cross Stochastic kinetic models are ubiquitous in physics, yet inferring their parameters from experimental data remains challenging. In deterministic models, parameter inference often relies on gradients, as they can be obtained efficiently through automatic differentiation. However, these tools cannot be directly applied to stochastic simulation algorithms (SSA) such as the Gillespie algorithm, since sampling from a discrete set of reactions