CARE: Confidence-aware Ratio Estimation for Medical Biomarkers

ArXi:2505.19585v3 Announce Type: replace Ratio-based biomarkers (RBBs), such as the proportion of necrotic tissue within a tumor, are widely used in clinical practice to diagnosis, prognosis, and treatment planning. These biomarkers are typically estimated from segmentation outputs by computing region-wise ratios. Despite the high-stakes nature of clinical decision making, existing methods provide only point estimates, offering no measure of uncertainty. In this work, we propose a unified confidence-aware framework for estimating ratio-based biomarkers.