AI RESEARCH

FluoCLIP: Stain-Aware Focus Quality Assessment in Fluorescence Microscopy

arXiv CS.CV

ArXi:2602.23791v2 Announce Type: replace-cross Accurate focus quality assessment (FQA) in fluorescence microscopy is challenging due to stain-dependent optical variations that induce heterogeneous focus behavior across images. Existing methods, however, treat focus quality as a stain-agnostic problem, assuming a shared global ordering. We formulate stain-aware FQA for fluorescence microscopy, showing that focus-rank relationships vary substantially across stains due to stain-dependent imaging characteristics and invalidate this assumption. To this formulation, we.