AI RESEARCH
Shortcut Learning in Glomerular AI: Adversarial Penalties Hurt, Entropy Helps
arXiv CS.CV
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ArXi:2604.07936v1 Announce Type: new Stain variability is a pervasive source of distribution shift and potential shortcut learning in renal pathology AI. We ask whether lupus nephritis glomerular lesion classifiers exploit stain as a shortcut, and how to mitigate such bias without stain or site labels. We curate a multi-center, multi-stain dataset of 9{,}674 glomerular patches (224$\times$224) from 365 WSIs across three centers and four stains (PAS, H\&E, Jones, Trichrome), labeled as proliferative vs.\ non-proliferative.