AI RESEARCH
CryoSplat: Gaussian Splatting for Cryo-EM Homogeneous Reconstruction
arXiv CS.CV
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ArXi:2508.04929v4 Announce Type: replace-cross As a critical modality for structural biology, cryogenic electron microscopy (cryo-EM) facilitates the determination of macromolecular structures at near-atomic resolution. The core computational task in single-particle cryo-EM is to reconstruct the 3D electrostatic potential of a molecule from noisy 2D projections acquired at unknown orientations. Gaussian mixture models (GMMs) provide a continuous, compact, and physically interpretable representation for molecular density and have recently gained interest in cryo-EM reconstruction.