Cross-Modal Knowledge Distillation from Spatial Transcriptomics to Histology

ArXi:2604.09076v1 Announce Type: new Spatial transcriptomics provides a molecularly rich description of tissue organization, enabling unsupervised discovery of tissue niches -- spatially coherent regions of distinct cell-type composition and function that are relevant to both biological research and clinical interpretation. However, spatial transcriptomics remains costly and scarce, while H&E histology is abundant but carries a less granular signal.