AI RESEARCH
SIMPLER: H&E-Informed Representation Learning for Structured Illumination Microscopy
arXiv CS.CV
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ArXi:2604.10334v1 Announce Type: new Structured Illumination Microscopy (SIM) enables rapid, high-contrast optical sectioning of fresh tissue without staining or physical sectioning, making it promising for intraoperative and point-of-care diagnostics. Recent foundation and large-scale self-supervised models in digital pathology have nstrated strong performance on section-based modalities such as Hematoxylin and Eosin (H&E) and immunohistochemistry