Cyclic 2.5D Perceptual Loss for Cross-Modal 3D Medical Image Synthesis: T1w MRI to Tau PET

ArXi:2406.12632v3 Announce Type: replace-cross Positron emission tomography (PET) provides molecular biomarkers for Alzheimer's disease and related dementias (ADRD) and is increasingly used for diagnosis, staging, and clinical trial enrichment. However, its use is limited by cost, regulatory restrictions, and the invasiveness of radiotracer injection. Although current frameworks emphasize multimodal biomarker assessment, including the amyloid/tau/neurodegeneration (A/T/N) scheme, these barriers constrain access to PET imaging.