AI RESEARCH
ConforNets: Latents-Based Conformational Control in OpenFold3
arXiv CS.LG
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ArXi:2604.18559v1 Announce Type: cross Models from the AlphaFold (AF) family reliably predict one dominant conformation for most well-ordered proteins but struggle to capture biologically relevant alternate states. Several efforts have focused on eliciting greater conformational variability through ad hoc inference-time perturbations of AF models or their inputs. Despite their progress, these approaches remain inefficient and fail to consistently recover major conformational modes.