Predicting RNA 3D structure and conformers using a pre-trained secondary structure model and structure-aware attention

Nature Machine Intelligence, Published online: 21 April 2026; doi:10.1038/s42256-026-01223-x Wang and colleagues present trRosettaRNA2, a deep learning-based system for accurate RNA 3D structure prediction. By integrating end-to-end learning with secondary structure priors, it provides a powerful way to explore RNA structure and dynamics.