Flow matching for generative modelling in bioinformatics and computational biology

Nature Machine Intelligence, Published online: 23 April 2026; doi:10.1038/s42256-026-01220-0 Flow matching has emerged as a promising solution to mapping arbitrary pairs of high-dimensional data distributions, well suited to problems in molecular and cell biology. Morehead review the theoretical foundations of flow-matching-based models and applications of flow matching in computational biology, and discuss its role in developing methods towards an AI-based virtual cell.