AI RESEARCH
Computational Design and Experimental Validation of Photoactive PARP1 Inhibitors
arXiv CS.LG
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ArXi:2604.24634v1 Announce Type: cross Light-activated drugs are a promising way to treat localized diseases for which existing treatments have severe side effects. However, their development is complicated by the set of photophysical and biological properties that must be simultaneously optimized. Here we used computational techniques to find a set of promising candidates for the photoactive inhibition of the poly(ADP-ribose) polymerase 1 (PARP1) cancer target.