AI RESEARCH
RCSB PDB AI Help Desk: retrieval-augmented generation for protein structure deposition support
arXiv CS.AI
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ArXi:2604.22800v1 Announce Type: cross Motivation: Structural Biologists have contributed than 245,000 experimentally determined three-dimensional structures of biological macromolecules to the Protein Data Bank (PDB). Incoming data are validated and biocurated by ~20 expert biocurators across the wwPDB. RCSB PDB biocurators who process than 40% of global depositions face increasing challenges in maintaining efficient Help Desk operations, with approximately 19,000 messages in approximately 8,000 entries received from depositors in 2025.