AI RESEARCH
Reduced NEXI protocol for the quantification of human gray matter microstructure on the Connectome 2.0 scanner
arXiv CS.AI
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ArXi:2509.09513v2 Announce Type: replace-cross Biophysical diffusion MRI models like Neurite Exchange Imaging (NEXI) are essential for probing gray matter microstructure, estimating compartment diffusivities, neurite fraction, and exchange time. However, NEXI's multi-shell, multi-diffusion-time requirements cause prohibitively long acquisitions. Leveraging the Connectome 2.0 ultra-high gradient scanner, we developed a time-efficient protocol using an Explainable AI (XAI) framework.