AI RESEARCH
Protein-Conditioned Multi-Objective Reinforcement Learning for Full-Length mRNA Design
arXiv CS.LG
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ArXi:2605.01513v1 Announce Type: new Designing therapeutic messenger RNA (mRNA) requires creating full-length transcripts that carefully balance stability, translation efficiency, and immune safety. To address this challenge, we propose ProMORNA, a multi-objective generation framework that produces complete mRNA transcripts \textit{de novo} directly from a target protein sequence. Our approach begins by