Prompt Group-Aware Training for Robust Text-Guided Nuclei Segmentation

ArXi:2603.06384v1 Announce Type: cross Foundation models such as Segment Anything Model 3 (SAM3) enable flexible text-guided medical image segmentation, yet their predictions remain highly sensitive to prompt formulation. Even semantically equivalent descriptions can yield inconsistent masks, limiting reliability in clinical and pathology workflows. We reformulate prompt sensitivity as a group-wise consistency problem. Semantically related prompts are organized into \emph{prompt groups} sharing the same ground-truth mask, and a prompt group-aware.