AI RESEARCH
PepEDiff: Zero-Shot Peptide Binder Design via Protein Embedding Diffusion
arXiv CS.AI
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ArXi:2601.13327v2 Announce Type: replace We present PepEDiff, a novel peptide binder generator that designs binding sequences given a target receptor protein sequence and its pocket residues. Peptide binder generation is critical in therapeutic and biochemical applications, yet many existing methods rely heavily on intermediate structure prediction, adding complexity and limiting sequence diversity.