AI RESEARCH
HDTree: Generative Modeling of Cellular Hierarchies for Robust Lineage Inference
arXiv CS.LG
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ArXi:2506.23287v2 Announce Type: replace In single-cell research, tracing and analyzing high-throughput single-cell differentiation trajectories is crucial for understanding biological processes. Key to this is the robust modeling of hierarchical structures that govern cellular development. Traditional methods face limitations in computational cost, performance, and stability. VAE-based approaches have made strides but still require branch-specific network modules, limiting their scalability and stability, while often suffering from posterior collapse. To overcome these challenges, we.