AI RESEARCH
scHelix: Asymmetric Dual-Stream Integration via Explicit Gene-Level Disentanglement
arXiv CS.LG
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ArXi:2605.18576v1 Announce Type: new A critical challenge in single-cell RNA sequencing (scRNA-seq) integration is resolving the tension between eliminating batch effects and maintaining biological fidelity. While recent evidence indicates that batch effects manifest heterogeneously across genes, most existing methods process the transcriptome uniformly, frequently resulting in over-correction and loss of subtle biological signals.