AI RESEARCH

Fast reconstruction of degenerate populations of conductance-based neuron models from spike times

arXiv CS.LG

ArXi:2509.12783v2 Announce Type: replace-cross Inferring the biophysical parameters of conductance-based models (CBMs) from experimentally accessible recordings remains a central challenge in computational neuroscience. Spike times are the most widely available data, yet they reveal little about which combinations of ion channel conductances generate the observed activity. This inverse problem is further complicated by neuronal degeneracy, where multiple distinct conductance sets yield similar spiking patterns. We.