AI RESEARCH
Transforming H&E images into IHC: A Variance-Penalized GAN for Precision Oncology
arXiv CS.CV
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ArXi:2506.18371v2 Announce Type: replace-cross The overexpression of the human epidermal growth factor receptor 2 (HER2) in breast cells is a key driver of HER2-positive breast cancer, a highly aggressive subtype requiring precise diagnosis and targeted therapy. Immunohistochemistry (IHC) is the standard technique for HER2 assessment but is costly, labor-intensive, and highly dependent on antibody selection. In contrast, hematoxylin and eosin (H&E) staining, a routine histopathological procedure, offers broader accessibility but lacks HER2 specificity.