Null Results From An Orexin RCT

Over the last few months we have been doing a sleep experiment inspired by our suspicion that orexin is an exciting target for sleep need reduction. We mildly deprived ourselves of sleep (5-5.5 hours, relative to 7-7.5 hours normally) and took either a placebo or orexin intranasally. We tracked our sleep the night before and after taking a dose in the morning and completed various tests of mental acuity during the day. The results from our initial experiment are exclusively null results that don’t cross standard thresholds for statistical significance.